Wet cupping therapy (WCT) "Turks say hacamat along with other persian name is hijamat" is a simple and economic treatment that still needs scientific interpretation. It treated - Cupping therapy
effectively diseases with some other etiologies and pathogeneses e.g. rheumatoid arthritis symptoms (RA), hypertension, migraine,
cts (CTS), fibromyalgia, cellulitis while others. Here, we review medical and scientific bases
underlying cupping therapy and introduce Taibah theory as being a novel evidence-based scientific mechanism to clarify
it. Briefly, in Taibah theory, WCT is a minor surgical excretory procedure related scientifically towards the principles of
renal glomerular filtration and abscess evacuation, in which a pressure-dependent excretion of causative pathological
substances (CPS) occurs. CPS include disease-causing substances and disease-related substances (that result
during disease pathogenesis). Negative pressure used on skin surface causes local variety of filtered and
interstitial fluids containing CPS at skin upliftings inside cups. Scarifying skin upliftings accompanied by cupping causes
a pressure gradient plus a traction force across the skin and capillaries to excrete collected fluids with CPS and
cause bleeding at puncture sites. This increases filtration at both capillary ends to result in clearance of blood and
interstitial spaces from CPS. WCT benefits from the suction pressure, phenomenon of reactive hyperemia, nitric oxide supplement
production and skin scarifications (openings in skin barrier) in enhancing natural excretory skin functions, improving
lymphatic and capillary circulations and restoring homeostasis. Reported CPS of RA include autoantibodies, immune
complexes, soluble interleukin-2 receptors, inflammatory mediators, certain cytokines, prostaglandins, toxic cellular
products and rheumatoid factor, while CPS of CTS include malondialdehyde, interleukin 6, prostaglandin PGE- 2
and progressive edema (causing pain). WCT-induced filtration pressure may excrete those CPS in cupped blood.
Prophetic medicine (related to Prophet Mohammad peace be upon him) recommends WCT: �The best among
whatever you use in therapy is Al-hijamah (prophetic technique of WCT / hacamat tedavisi)�. In conclusion, WCT has scientific bases in
treating different diseases is the only treatment that clears blood and interstitial fluid from CPS.Therapeutic
advantages of WCT is related to the amount of excreted CPS not the quantity of letted blood. - Cupping therapy